Viral Hepatitis
GB virus-B may be a viral surrogate for testing hepatitis C therapy
Published in Hepatitis Weekly, October 13th, 2003
According to a study from the United States, "the GB virus-B (GBV-B) nonstructural protein 513 (NS5B) encodes an RNA-dependent RNA polymerase (RdRp) with greater than 50% sequence similarity to the hepatitis C virus (HCV) NS5B. Recombinant GBV-B NS5B was reported to possess RdRp activity (W. Zhong et al., J Viral Hepat, 2000;7:335-342)."
"In this study, the GBV-B RdRp was examined more thoroughly for different RNA synthesis activities, including primer-extension, de novo initiation, template switch, terminal nucleotide addition, and template specificity," stated C.T. Ranjith-Kumar...
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Source: Hepatitis Weekly (2003-10-13)
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