Antiviral Therapy
Plant compounds from Stylogne cauliflora block hepatitis C virus protease
Published in Hepatitis Weekly, October 13th, 2003
According to a study from the United States, "the 70% aqueous ruethanolic extract of the Peruvian plant Stylogne cauliflora was found to contain two novel oligophenolic compounds SCH 644343 (1) and SCH 644342 (2), which were identified as inhibitors of HCV NS3 protease."
"The structure of 1 and 2 was established based on high-resolution NMR studies. Compound 1 inhibited HCV NS3 protease with an IC50 of 0.3 micro M, while compound 2 showed an IC50 of 0-8 micro M," reported V.R. Hegde and colleagues, who work at Schering Plough Research Institute
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Source: Hepatitis Weekly (2003-10-13)
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