Genomics
Antisense oligodeoxynucleotides targeting Hsp60 block human HBV replication
Published in Hepatitis Weekly, November 24th, 2003
"The major role of hepatitis B virus polymerase (HBV pol) is polymerization of nucleotides, but it also participates in protein priming and the packaging of its own genome into capsids. Therefore, HBV pol may require many assistance factors for its roles. Previous reports have shown that Hsp60, a molecular chaperone, activates HBV pol both in vitro and ex vivo, such as inside insect cells," scientists writing in the Journal of Biological Chemistry report.
"Moreover, HBV pol binds to Hsp60 in the HepG2 host cell line. In this report, we show that Hsp60 plays a role in...
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Source: Hepatitis Weekly (2003-11-24)
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