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Fatty Liver Disease

Long-term rosiglitazone improves the markers of nonalcoholic steatohepatitis

Published in Hepatitis Weekly, December 1st, 2003

Long-term rosiglitazone improves the markers of nonalcoholic steatohepatitis.

"Insulin resistance (IR) commonly is associated with nonalcoholic steatoliepatitis (NASH). To establish whether IR causes NASH, this study was undertaken to determine if improving IR would improve the histologic features that define NASH. Thirty adults with prior biopsy evidence of NASH were enrolled to receive rosiglitazone, 4 mg twice daily for 48 weeks," scientists in the United States report.

"All patients were overweight (body mass index [BMI] > 25 kg/m2) and 23% were severely obese (BMI > 35 kg/m2); 50% had impaired glucose tolerance or...

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