Published in Hepatitis Weekly, December 8th, 2003
"Hepatitis B virus (hepadnavirus) infections are maintained by the presence of a small and regulated number of episomal viral genomes [covalently closed circular DNA (cccDNA)] in the nuclei of infected cells. Although a number of studies have measured the mean copy number of cccDNA molecules in hepadnaviral-infected cells, the distribution of individual copy numbers have not been reported," according to research published in the journal Proceedings of the National Academy of Sciences USA.
"Using a polymerase chain reaction (PCR)-based assay, we examined the number of cccDNA molecules...
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