Bone Marrow Transplantation

In non-HLA identical bone marrow transplant, T-cell incompatibility is high risk

Published in Hepatitis Weekly, December 8th, 2003

In non-HLA identical, minimally T cell depleted pediatric bone marrow transplant, the T and not the NK cell incompatibility led to increased GVHD and death.

"Natural killer (NK) cell alloreactivity resulting from killer immunoglobulin-like receptor (KIR) ligand incompatibility improves outcomes in patients receiving extensively T cell-depleted bone marrow (BM) grafts," scientists writing in the British Journal of Haematology report.

"Patients with KIR ligand incompatibility are at risk for donor T cell alloreactivity. We investigated the relative significance of NK-cell and T cell alloreactivity in 105 pediatric patients who received a...

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Source: Hepatitis Weekly (2003-12-08)

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