Chronic Hepatitis B
Lamivudine-resistant patients develop compensatory mutations during therapy
Published in Hepatitis Weekly, December 8th, 2003
"Therapy of chronic hepatitis B virus (HBV) infection with the polymerase inhibitor lamivudine frequently is associated with the emergence of viral resistance. Genotypic changes in the YMDD motif (reverse transcriptase [rt] mutations rtM204V/I) conferred resistance to lamivudine as well as reducing the in vitro replication efficiency of HBV. A second mutation, rtL180M, was previously reported to partially restore replication fitness as well as to augment drug resistance in vitro," according to a study from the United States.
"Here we report the functional characterization of...
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Source: Hepatitis Weekly (2003-12-08)
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