Published in Hepatitis Weekly, December 22nd, 2003
"Nucleotide sequence analysis of multiple molecular clones of the hepatitis A virus (HAV), generated by reverse transcription-polymerase chain reaction of two capsid-coding regions, revealed a degree of heterogeneity compatible with a quasispecies structure in three clinical samples," according to researchers in Spain.
"Passage of plaque-purified reference strain HAV pHM175 43c in FRhK-4 cells documented the generation of a mutant distribution of HAV genomes. The mutant spectra showed mutation frequencies in the range of 1 x 10-3 to 1 x 10-4 substitutions per...
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