Tumor Markers

Pancreatic endocrine neoplasms are more likely to have p27 if metastasizing

Published in Hepatitis Weekly, December 29th, 2003

Pancreatic endocrine neoplasms (PENs) are more likely to have p27 if metastasizing, and to retain p27 expression once metastasized.

According to a study from the United States, "decreased expression of p27 occurs in aggressive colon, breast, and prostate neoplasms; p27 loss often correlates with worsened prognosis. Paradoxical overexpression has been described in benign and malignant PENs.

"To investigate prognostic usefulness of p27 expression in PENs, we immunolabeled 42 primary PENs, with or without metastasis for p27, separating lesions using a nuclear labeling index (NLI) of 10%. Of the 42 lesions, 26 demonstrated an NLI >10%, and 16 an NLI...

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Source: Hepatitis Weekly (2003-12-29)

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