Virology
A benzothiadiazine inhibitor blocks hepatitis C virus replicase function
Published in Hepatitis Weekly, December 29th, 2003
"Recently, a benzo-1,2,4-thiadiazine antiviral agent (C21H21N3O4S; compound 4) was shown to be a potent, highly specific inhibitor of the primary catalytic enzyme of the hepatitis C virus (HCV) replicase complex. In this study, we selected for resistance to confirm the mechanism of action for compound 4 in HCV replicon cells. As expected, spontaneous mutations or fluidity in the HCV polymerase (NS5B) coding sequence occurred upon routine passage of the HCV replicon cells in the absence of compound 4," investigators in the United States reported.
"After 1 month of culture in the...
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Source: Hepatitis Weekly (2003-12-29)
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