Transgenics
Rodents with inducible suicide genes will advance liver disease drug research
Published in Hepatitis Weekly, January 12th, 2004
According to published research from Japan, "suicide gene expression in specific tissue of transgenic animals has been used for cell-specific ablation. To examine the influence of hepatocyte removal, we produced the herpes simplex virus thymidine kinase (HSVtk) transgenic rat, whose gene was regulated by an albumin enhancer promoter. The liver presence of HSVtk was demonstrated in one line of the transgenic rats."
"We injected ganciclovir (GCV, 50 mg/kg) into the rat on alternate days. After 28 days of GCV administration, liver tissues and blood of the rats were...
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Source: Hepatitis Weekly (2004-01-12)
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