Published in Hepatitis Weekly, January 26th, 2004
According to recent research published in the Journal of Virology, "two template switches are necessary during plus-strand DNA synthesis of the relaxed circular (RC) form of the hepadnavirus genome. The 3' end of the minus-strand DNA makes important contributions to both of these template switches. It acts as the donor site for the first template switch, called primer translocation, and subsequently acts as the acceptor site for the second template switch, termed circularization."
"A small DNA hairpin has been shown to form near the 3' end of the minus-strand DNA...
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