Iron Overload
HFE gene mutations associate with fibrosis in chronic hepatitis C patients
Published in Hepatitis Weekly, February 2nd, 2004
"Mild iron overload in chronic hepatitis C is associated with liver fibrosis, hepatitis C virus (HCV) genotype 1b infection, and an impaired response to interferon therapy. In this study we evaluated whether polymorphisms in the hemochromatosis gene HFE and the transferrin receptor gene TFR1 are associated with these typical findings. The study considered 246 HCV-infected patients and 200 blood donors as controls, in which C282Y, H63D, and S65C mutations (HFE) and the S142G polymorphism (TFR1) were detected," scientists writing in the Journal of Molecular Medicine report.
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Source: Hepatitis Weekly (2004-02-02)
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