Published in Hepatitis Weekly, March 8th, 2004
"RNA structures play key roles in the replication of RNA viruses. Sequence alignment software, thermodynamic RNA folding programs, and classical comparative phylogenetic analysis were used to build models of six RNA elements in the coding region of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B. The importance of five of these elements was evaluated by site-directed mutagenesis of a subgenomic HCV replicon," investigators in the United States report.
"Mutations disrupting one of the predicted stem-loop structures, designated 5BSL3.2, blocked RNA...
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