Mutagenesis
Altered iron associates with mutations in those with chronic hepatitis C
Published in Hepatitis Weekly, March 8th, 2004
According to published research from Germany, "hepatitis C virus infection is often associated with an elevation of iron parameters. Free liver iron causes liver damage and liver fibrosis preferentially through induction of reactive oxygen species. With an allele frequency of 5-10% for the C282Y mutation and 6-30% for the H63D mutation, there is a frequent coincidence of hemochromatosis (HFE) mutations and chronic hepatitis C."
"There is increasing evidence that HFE homozygosity and even HFE heterozygosity are associated with an increased liver iron concentration and...
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Source: Hepatitis Weekly (2004-03-08)
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