Cell Biology
Hepatitis C virus relies on cellular proliferation for genomic replication
Published in Hepatitis Weekly, March 8th, 2004
"Considerable controversy surrounds the impact of hepatitis C virus (HCV) protein expression on viability of host cells and regulation of the cell cycle. Both promotion of cellular proliferation and apoptosis have been observed in different experimental systems," investigators in the United States say.
"To determine whether expression of the entire complement of HCV proteins in the context of ongoing viral RNA replication significantly alters the host cell transcriptome and cell cycle regulatory processes, we carried out high-density oligonucleotide microarray studies and...
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Source: Hepatitis Weekly (2004-03-08)
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