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Hepatitis E Virus

Genetic changes and strain takeover mark HEV genotype variability in India

Published in Hepatitis Weekly, March 22nd, 2004

Genetic changes and strain takeover mark HEV genotype variability in India.

"To investigate the genetic changes in hepatitis E virus (HEV) strains in the Kathmandu valley of Nepal, we compared the 412 nt sequence within open reading frame 2 of HEV among HEV isolates recovered from 16 patients in 1999, 14 patients in 2000 and 38 patients in 2002, and additional isolates recovered from 48 patients in 1997 whose nucleotide sequences have been previously published," scientists writing in the Journal of General Virology report.

"All 116 HEV-viremic samples were genotyped as 1 and subtyped further as 1a (n=85, 73%), 1c (n=29, 25 %) and mixed...

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