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Transplant Medicine

Cytokine genes are key to hepatitis C virus recurrence in liver graft patients

Published in Hepatitis Weekly, April 19th, 2004

Cytokine genes are key to hepatitis C virus recurrence in liver graft patients.

"Acute rejection (AR) and recurrence of hepatitis C virus (HCV) infection are complications after liver transplantation (LTx). Genetic factors play a role in cytokine production as a consequence of polymorphisms within cytokine genes. Our goal was to identify genetic factors that might be associated with AR and recurrence of HCV in liver transplant recipients (LTxRs)," investigators in the United States report.

"We studied 77 Caucasian LTxRs and 100 Caucasian healthy individuals. We studied single-nucleotide polymorphisms (SNPs) in tumor necrosis factor-alpha (TNF-alpha),...

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