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Angiology

Contrast agent concentration in mouse blood used to determine tumor vascularity

Published in Hepatitis Weekly, April 19th, 2004

Contrast agent concentration in mouse blood in vivo is useful for the determination of tumor vascularity.

"A method for measuring contrast agent concentration in blood was developed using a switchable RF tail coil to obtain MR signal from the mouse tail vein. The switchable RF coil was used to obtain quantitative high-resolution T-1 maps of the tail in combination with a second coil used to obtain images from regions of interest in a mouse tumor model. The effect of flow rates on the T-1 measurements was validated using a flow-phantom," scientists at Johns Hopkins University reported.

"Reliable estimates of blood T-1 were obtained for flow rates up...

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