Drug Development
N-terminally PEGylated interferon-beta yields improved pharmacology
Published in Hepatitis Weekly, May 10th, 2004
According to recent research published in the journal Protein Expression and Purification, "to identify potential new clinical uses and routes of administration for human interferon-beta-1a (IFN-beta-1a), we have developed an expression and purification procedure for the preparation of highly purified rat interferon-beta (IFN-beta) suitable for testing in rat models of human disease. An expression vector containing the rat IFN-beta signal sequence and structural gene was constructed and transfected into Chinese hamster ovary (CHO) cells. The protein was purified from CHO cell conditioned medium...
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Source: Hepatitis Weekly (2004-05-10)
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