Transplant Medicine

Researchers report a possible technique for expanding the donor liver pool

Published in Hepatitis Weekly, May 10th, 2004

Heat shock preconditioning (HPc) in a rat fatty liver model resulted in much higher organ survival rate, researchers report.

"Fatty liver is a common predisposing risk factor for postoperative liver failure and accounts for most discarded livers during triage of donors. We investigated the effect of HPc on recipient survival in a rat fatty liver transplantation model," scientists in the United States report.

"Fatty liver donor rats were exposed to brief whole-body hyperthermia (10 minutes at 42.5 degrees C and allowed to recover. HPc induced heat shock proteins (HSPs) (HSP72, HSP90, and heme oxygenase [HO]-1) in donor livers, with levels peaking 12...

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Source: Hepatitis Weekly (2004-05-10)

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