Published in Hepatitis Weekly, May 10th, 2004
According to researchers in Japan, "we investigated how the hepatitis C virus (HCV) core protein affects the cell cycle profile and cell cycle-related molecules by using the HCV core-expressing stable transfectant. Analysis of the cell cycle profile showed that HCV core impaired G1 to S transition. The E2F-mediated transcription, phosphorylation of the retinoblastoma protein, and cyclin-dependent kinase (CDK) 4 and CDK2 activities were suppressed in HCV core-expressing cells.
"The expression levels of G1 phase-related CDKs/cyclins and various CDK inhibitors were not substantially affected...
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