Hepatology

Cyclosporine reduces hepatic antioxidant capacity

Published in Hepatitis Weekly, May 24th, 2004

Cyclosporine A (CsA) treatment reduces antioxidant activity in the liver.

CsA "has been reported to exert measurable hepatotoxic effects," scientists in Turkey explained. "One of the causes leading to hepatotoxicity is thought to be reactive oxygen radical formation.

"Therefore", I. Durak and colleagues at Ankara University conducted a study "to elucidate [a] possible relation between cyclosporine A treatment and antioxidant capacity (AOC) of hepatic tissue, and to determine if antioxidant supplementation is beneficial.

"Cyclosporine A was given to 20 rabbits orally for 10 days," according to the report. "Vitamins E and C...

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Source: Hepatitis Weekly (2004-05-24)

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