Published in Hepatitis Weekly, May 24th, 2004
"The lipid raft membrane has been shown to be the site of hepatitis C virus (HCV) RNA replication. The mechanism of formation of the replication complex is not clear. We show here that the formation of the HCV RNA replication complex on lipid raft (detergent-resistant membranes) requires interactions among the HCV nonstructural (NS) proteins and may be initiated by the precursor of NS4B, which has the intrinsic property of anchoring to lipid raft membrane," researchers in the United States report.
"In hepatocyte cell lines containing an HCV RNA replicon, most of the other NS...
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