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Chronic Liver Disease

Ursodeoxycholic acid doesn't resolve nonalcoholic steatohepatitis

Published in Hepatitis Weekly, May 24th, 2004

Ursodeoxycholic acid doesn't resolve nonalcoholic steatohepatitis.

According to recent research published in the journal Hepatology, "no effective medical therapy is available for all patients with nonalcoholic steatohepatitis (NASH). Ursodeoxycholic acid (UDCA) has been suggested to be of benefit based on open label clinical studies. We randomized 166 patients with liver biopsy proven NASH to receive between 13 and 15 mg/kg/d of UDCA or placebo for 2 years."

"End points included changes in liver test results and liver histology at 2 years of therapy. The treatment groups were comparable at entry with regard to age, gender, risk factors for...

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