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Hepatitis C Vaccine

Hepatitis C-derived lipopeptides induced antibody-producing T cells

Published in Hepatitis Weekly, June 14th, 2004

Hepatitis C virus (HCV)-derived lipopeptides induced antibody-producing T lymphocytes.

"We analyzed whether hepatitis C virus (HCV)-specific antibody-producing B lymphocytes can be induced in vitro with HCV-derived lipopeptides containing different T helper cell epitopes. HCV-specific antibody-producing B cells were detected by ELISPOT at the single cell level. HCV-derived lipopeptides, but not their corresponding unlipidated peptides, induced B lymphocytes, which produced antibodies mainly reacting with the HCV-derived lipopeptides," researchers in Germany report.

"The number of antigen-specific B cells was dependent on the number of added...

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