Hepatitis
Hepatitis A virus cDNA-transfected Ltk-cells might reveal viral pathogenesis
Published in Hepatitis Weekly, June 21st, 2004
According to a study from the United States, "hepatitis A virus (HAV) has stringent replication requirements and a restricted host-range. Mouse Ltk-cells do not support growth of HAV upon infection or transfection of virion RNA. However, low levels of HAV were rescued from Ltk- cells transiently transfected with its infectious cDNA."
"Ltk- stable transfectants that expressed HAV antigens and produced infectious HAV were selected and termed Ltk-pJH15 cells. After a few serial passages, HAV became undetectable in the Ltk-pJH15 cells. Multiple rounds of single cell cloning of...
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Source: Hepatitis Weekly (2004-06-21)
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