Viral Genomics and Genetics

Purine ribonucleosides rely on unique relationships for hepatitis C inhibition

Published in Hepatitis Weekly, June 28th, 2004

Purine ribonucleosides rely on unique relationships for hepatitis C inhibition.

"As part of a continued effort to identify inhibitors of hepatitis C viral (HCV) replication, we report here the synthesis and evaluation of a series of nucleoside analogues and their corresponding triphosphates. Nucleosides were evaluated for their ability to inhibit HCV RNA replication in a cell-based, subgenomic replicon system, while nucleoside triphosphates were evaluated for their ability to inhibit in vitro RNA synthesis mediated by the HCV RNA-dependent RNA polymerase, NS5B," researchers in the United States report.

"2'-C-Methyladenosine and 2'-C-methylguanosine...

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Source: Hepatitis Weekly (2004-06-28)

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