Chronic Liver Disease
A four-step model outlines the progress of non-alcoholic steatohepatitis
Published in Hepatitis Weekly, June 28th, 2004
"Fatty liver disease involves the accumulation of triglycerides in hepatocytes, necrosis of hepatocytes, inflammation, and often fibrosis with progression to cirrhosis. The two-hit model summarizes the important early metabolic events leading to hepatocellular necrosis in non-alcoholic steatohepatitis (NASH). In this article, we provide evidence of lipid release from hepatocytes in post-transplant fat necrosis and in NASH and quantify vascular obliteration in a series of biopsies with NASH," investigators in Canada report.
"Obliteration of small hepatic veins (<30 mcm) in...
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Source: Hepatitis Weekly (2004-06-28)
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