Published in Hepatitis Weekly, June 28th, 2004
"Fatty liver disease involves the accumulation of triglycerides in hepatocytes, necrosis of hepatocytes, inflammation, and often fibrosis with progression to cirrhosis. The two-hit model summarizes the important early metabolic events leading to hepatocellular necrosis in non-alcoholic steatohepatitis (NASH). In this article, we provide evidence of lipid release from hepatocytes in post-transplant fat necrosis and in NASH and quantify vascular obliteration in a series of biopsies with NASH," investigators in Canada report.
"Obliteration of small hepatic veins (<30 mcm) in...
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