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Liver Injury

The CXCR3 ligand I-TAC correlates with chronic hepatitis C-related inflammation

Published in Hepatitis Weekly, July 5th, 2004

The CXCR3 ligand I-TAC correlates with chronic hepatitis C-related inflammation.

According to recent research from Australia, "the factors that regulate lymphocyte traffic in chronic hepatitis C (CHC) are not completely defined. Interferon (IFN)-inducible T cell alpha chemoattractant (I-TAC) is a relatively new member of the CXCR3 chemokine ligand family that selectively recruits activated T cells to sites of inflammation. To determine if I-TAC plays a role in CHC, we investigated I-TAC expression in hepatitis C virus (HCV)-infected liver biopsy material."

"I-TAC messenger RNA (mRNA) levels were significantly increased in HCV-infected liver compared...

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