Hepatitis C Vaccine

Immunization with hepatitis C core gene triggers T-cell response

Published in Hepatitis Weekly, July 12th, 2004

Immunization with hepatitis C virus core gene triggers potent T-cell response, but affects CD4+T-cells.

"Numerous attempts to induce immunity against HCV core (HCV-C) by DNA immunization met serious difficulties in optimizing T-helper cell and antibody responses. Immunomodulatory properties of HCV-C could be blamed that seem to be dependent on the genotype of HCV source. Here, we characterized HCV-C gene from HCV lb isolate 274933RU," scientists writing in the journal Vaccine report.

"Eukaryotic expression of HCV-C was effectively driven by CMVIE, while human elongation factor I alpha promoter directed low levels of HCV-C expression," said...

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Source: Hepatitis Weekly (2004-07-12)

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