Gene Expression
Hepatocyte nuclear factor-1beta-regulated genes identified
Published in Hepatitis Weekly, August 16th, 2004
"The identification of genes targeted by a specific transcription regulatory factor (TRF) is essential to our understanding of the regulatory mechanism of gene expression.
"We constructed a system for the comprehensive identification of genes directly regulated by a TRF. It includes a combination of perturbation of gene expression by RNA interference (RNAi) of the TRF, cDNA microarray analysis, computer searches for the putative TRF recognition sequences, and in vivo and in vitro TRF-DNA binding assays," researchers in Japan report.
"Endogenous hepatocyte...
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Source: Hepatitis Weekly (2004-08-16)
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