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Aplastic Anemia

T-cell repertoire returns to normal in HAA recovery

Published in Hepatitis Weekly, August 16th, 2004

T-cell repertoire was seen to return to normal in hepatitis-associated aplastic anemia recovery.

"Hepatitis-associated aplastic anemia (HAA) is a syndrome of bone marrow failure following an acute attack of seronegative hepatitis," researchers in the United States explained. "Clinical features and liver histology suggest a central role for an immune-mediated mechanism."

"To characterize the immune response, we investigated the T-cell repertoire (T-cell receptor [TCR] Vbeta chain subfamily) of intrahepatic lymphocytes in HAA patients by TCR spectratyping," J. Lu and colleagues at the U.S. National Heart, Lung, and Blood Institute reported. "In 6 of 7...

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