Hepatitis C Virus

Chemokines and CCR5 interaction critical in regulating T cell function

Published in Hepatitis Weekly, August 16th, 2004

Chemokines and their interaction with CCR5 is critical in regulating T cell function.

According to investigators in Germany, "An effective immune response to hepatitis C virus (HCV) infection requires efficient recruitment and activation of inflammatory cells to the liver, the site of infection. Chemokines are critically involved in this process, since they exert both chemotactic and immunoregulatory actions."

"In particular," wrote G. Ahlenstiel and colleagues, "the interaction between chemokines CCL3 (MIP-1alpha), CCL4 (MIP-1beta) and CCL5 (RANTES) and their receptor, CC-chemokine receptor 5 (CCR5), may be critical in regulating T cell functions by...

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Source: Hepatitis Weekly (2004-08-16)

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