Hepatitis C Virus

Enrichment technique to detect hepatitis-specific T cells studied

Published in Hepatitis Weekly, August 16th, 2004

A new enrichment technique to detect tetramer-positive, hepatitis C-specific T cells has been analyzed.

According to a study from England, "A major breakthrough in cellular immunology has been the development of HLA class I tetramers to analyze CD8+ T cell responses.

However, in many situations, including persistent virus infection, specific T cell responses are rarely detected using this technology. This raises the question of whether such responses are 'deleted' (or 'exhausted') or present below the conventional detection limit for class I tetramer staining."

"In particular," wrote E. Barnes and colleagues, University of Oxford,...

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Source: Hepatitis Weekly (2004-08-16)

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