Diagnostics
Ribozyme-based assays detect viral nucleic acids
Published in Hepatitis Weekly, September 6th, 2004
"Many reports have suggested that target-activated ribozymes hold potential value as detection reagents. We show that a 'half'-ribozyme ligase is activated similarly by three unstructured oligoribonucleotides representing the major sequence variants of a hepatitis C virus (HCV) 5'-untranslated region (5'-UTR) target and by a structured RNA corresponding to the entire 5'-UTR," investigators in the United States report.
"Half-ribozyme ligation product was detected both in an enzyme-linked immunosorbent (ELISA)-like assay and in an optical immunoassay through the use of hapten-carrying substrate RNAs,"...
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Source: Hepatitis Weekly (2004-09-06)
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