Published in Hepatitis Weekly, September 6th, 2004
"Many reports have suggested that target-activated ribozymes hold potential value as detection reagents. We show that a 'half'-ribozyme ligase is activated similarly by three unstructured oligoribonucleotides representing the major sequence variants of a hepatitis C virus (HCV) 5'-untranslated region (5'-UTR) target and by a structured RNA corresponding to the entire 5'-UTR," investigators in the United States report.
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