Stem Cell Research
Myelomonocytic cells sufficient for therapeutic cell fusion in liver
Published in Hepatitis Weekly, September 13th, 2004
According to a study from the United States, "Liver repopulation with bone marrow-derived hepatocytes (BMHs) can cure the genetic liver disease fumarylacetoacetate hydrolase (Fah) deficiency.
"BMHs emerge from fusion between donor bone marrow-derived cells and host hepatocytes. To use such in vivo cell fusion efficiently for therapy requires knowing the nature of the hematopoietic cells that fuse with hepatocytes."
"Here we show that the transplantation into Fah-/- mice of hematopoietic stem cells (HSCs) from lymphocyte-deficient Rag1-/- mice,...
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Source: Hepatitis Weekly (2004-09-13)
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