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Infection

A select series of steps guides hepatitis B virus entry into cells

Published in Hepatitis Weekly, September 27th, 2004

A select series of steps guides hepatitis B virus entry into cells.

"Little is known about cellular determinants essential for human hepatitis B virus infection. Using the duck hepatitis B virus as a model, we first established a sensitive binding assay for both virions and subviral particles and subsequently elucidated the characteristics of the early viral entry steps," scientists in Germany report.

"The infection itinerary was found to initiate with the attachment of viral particles to a low number of binding sites on hepatocytes (about 104 per cell)," said A. Funk and colleagues, Heinrich Pette Institute of Experimental Virology and Immunology,...

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