Virology
Common viruses use La autoantigen for IRES-dependent translation
Published in Hepatitis Weekly, September 27th, 2004
"Translation of poliovirus and hepatitis C virus (HCV) RNAs is initiated by recruitment of 40S ribosomes to an internal ribosome entry site (IRES) in the mRNA 5' untranslated region. Translation initiation of these RNAs is stimulated by noncanonical initiation factors called IRES trans-activating factors (ITAFs). The La autoantigen is such an ITAF, but functional evidence for the role of La in poliovirus and HCV translation in vivo is lacking," scientists writing in the journal Molecular and Cellular Biology report.
"Here, by two methods using small interfering RNA and a...
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Source: Hepatitis Weekly (2004-09-27)
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