Published in Hepatitis Weekly, October 18th, 2004
According to published research from the United States, "the nonstructural protein NS5B of hepatitis C virus (HCV) is an RNA-dependent RNA polymerase (RdRp), which plays a central role in viral replication. Most of the reported studies on HCV polymerase in vitro have used a truncated form of the enzyme lacking the C-terminal 21 amino acids (DeltaC(21)-NS5B). In this study, we compared the enzymatic properties of the full-length NS5B (FL-NS5B) and this truncated form."
"Removal of the C-21 domain enhanced the enzyme stability. Both enzymes are capable of performing de novo and...
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