Environmental Health
Gene profiling can be used to distinguish toxicant classes
Published in Hepatitis Weekly, November 1st, 2004
In a study from Switzerland, "[m]ale rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing."
The goal of these experiments was "to determine if biological samples from rats treated with various compounds can be classified based on gene expression profiles," explained G. Steiner and coauthors at F. Hoffmann-La Roche Ltd. in Basel. "In addition to gene expression analysis using microarrays, a complete serum chemistry profile and liver and...
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Source: Hepatitis Weekly (2004-11-01)
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