Malaria Therapy
Pyronaridine metabolism characterized in vitro and in vivo
Published in Hepatitis Weekly, November 15th, 2004
In a recent study from South Korea, "[i]n vitro incubation of pyronaridine with rat and human liver microsomes resulted in the formation of 11 metabolites, with pyronaridine quinoneimine (M3) as the major metabolite."
"The structures of pyronaridine metabolites were characterized on the basis of the product ion mass spectra obtained under low-energy collision-induced dissociation (CID) ion trap mass spectrometry," explained J. Lee and coauthors at the Korea Institute of Science and Technology in Seoul. "Both pyronaridine (m/z 518) and...
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Source: Hepatitis Weekly (2004-11-15)
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