Embryonic Stem Cell Research
Glycogen- and albumin-producing hepatocyte-like cells generated from ESCs
Published in Hepatitis Weekly, December 27th, 2004
According to published research from Germany, "We present a novel two-step protocol for the differentiation of embryonic stem (ES) cells into the hepatic lineage. Differentiated hepatocytelike cells express genes and proteins characteristic for endodermal and hepatic cells and acquire a functional hepatic phenotype as demonstrated by albumin secretion and glycogen storage."
"During differentiation, alpha-fetoprotein, albumin, transthyretin, alpha-1-antitrypsin, cytochrome P450 subunits 2b9 and 2b13 and tyrosine aminotransferase transcripts are...
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Source: Hepatitis Weekly (2004-12-27)
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