Enzymology
Hepatitis C virus NS3 protein mediates caspase-8-related apoptosis
Published in Hepatitis Weekly, January 10th, 2005
According to a study from the United States, "apoptosis has been implicated in the pathogenesis of hepatitis C virus (HCV)-related disease. Here, we show that expression of HCV NS3, or the NS2/NS3 precursor protein, in mammalian cells results in induction of apoptosis and activation of caspases. HCV NS3-induced apoptosis was blocked by a caspase-8, but not a caspase-9-specific inhibitor."
"HCV NS3 coimmunoprecipitated with caspase-8, but not with other caspases or with Fas-associated protein with death domain (FADD). Coexpression of HCV NS3 and caspase-8 resulted in aggregation of...
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Source: Hepatitis Weekly (2005-01-10)
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