Hepatocellular Carcinoma

Gene sets signal the therapeutic response of liver cancer to chemotherapy

Published in Hepatitis Weekly, January 10th, 2005

Gene sets signal the therapeutic response of liver cancer to chemotherapy.

According to published research from Japan, "recently, combined chemotherapy with 5-fluorouracil (5-FU) and interferon (IFN)-alpha has been reported to show marked effects in patients with advanced hepatocellular carcinoma. We investigated the genes associated with susceptibility to this combination therapy."

"The gene expression profiles of eight human hepatocellular carcinoma cells (HepG2, Hep3B, Huh7, Huh6, PLC/PRF/5, HLE, HLF, and SK-Hep1) were evaluated using an oligonucleotide microarray that consisted of 3800 genes," wrote M. Moriyama and colleagues, University of...

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Source: Hepatitis Weekly (2005-01-10)

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