Oncology
Anti-endostatin antibody reveals how endostatin fights liver cancer
Published in Hepatitis Weekly, January 10th, 2005
"Endostatin, a fragment of collagen XVIII, inhibits angiogenesis in tumors, and is expected to become a new anticancer drug. However, its effectiveness is still controversial, because some researchers failed to reproduce the same marked regression of tumors by the peptide," according to researchers in Japan.
"We gave anti-endostatin monoclonal antibody, designated as CH18B, to nude mice transplanted with human hepatocellular carcinoma cells (JHH-1 line) that endogenously produced endostatin from collagen XVIII secreted by the cells themselves," stated S. Tsuboi and colleagues,...
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Source: Hepatitis Weekly (2005-01-10)
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