Protein Regulation
Novel hepatitis C IRES-binding proteins support several cell activities
Published in Hepatitis Weekly, January 10th, 2005
"Hepatitis C virus (HCV) protein translation is mediated by a cis-acting RNA, an internal ribosomal entry site (IRES), located in the 5' nontranslated region of the viral RNA. To examine proteins bound to the IRES, which could include proteins important for its function as well as potential drug targets, we used shotgun peptide sequencing to identify proteins in quadruplicate protein affinity extracts of lysed Huh7 cells, obtained using a biotinylated IRES," wrote United States investigators.
"Twenty-six proteins bound the HCV IRES but not a reversed complementary sequence RNA...
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Source: Hepatitis Weekly (2005-01-10)
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