DNA Research

Trientine reduces DNA strand breaks in rodent liver cells

Published in Hepatitis Weekly, January 17th, 2005

Trientine reduces DNA strand breaks in rodent liver cells.

According to published research from Japan, "effects of treatment with trientine, a specific copper-chelating agent, on accumulation of copper and induction of DNA strand breaks were investigated in Long-Evans Cinnamon (LEC) rats, an animal model for human Wilson's disease."

"Copper accumulated in the livers of LEC rats in an age-dependent manner from 4 to 13 weeks of age. When LEC rats were treated with trientine from 10 weeks of age, hepatic copper contents did not increase and were maintained at the same levels as those in 10-week-old LEC rats," wrote M. Hayashi and colleagues, Rakuno...

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Source: Hepatitis Weekly (2005-01-17)

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