Drug Development
Schisandra fruit extract contains potent CYP3A4 inhibitors
Published in Hepatitis Weekly, January 31st, 2005
"Schisandra fruit, a Schisandraceae family herb, is used as a component in Kampo medicines (developed from Chinese medicines, but established in Japan)," scientists in Japan explained. "It can act as a sedative and antitussive, improve hepatic function, and give a general tonic effect."
"An extract of Schisandra fruit has been shown with a potent inhibitory effect on human liver microsomal erythromycin N-demethylation activity mediated by cytochrome P450 3A4 (CYP3A4)," noted H. Iwata and colleagues at Toyama Medical and Pharmaceutical University. They conducted a study "to identify...
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Source: Hepatitis Weekly (2005-01-31)
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