Published in Hepatitis Weekly, January 31st, 2005
According to recent research from the United States, "the Eastern woodchuck (Marmota monax) harbors a DNA virus (Woodchuck hepatitis virus [WHV]) that is similar in structure and replicative life cycle to the human hepatitis B virus (HBV). Like HBV, WHV infects the liver and can cause acute and chronic hepatitis. Furthermore, chronic WHV infection in woodchucks usually leads to development of hepatocellular carcinoma (HCC) within the first 2-4 years of life."
"The woodchuck model has been important in the preclinical evaluation of safety and efficacy of the antiviral...
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